Dissolution and Relative Bioavailability of CoQ10
Most CoQ10 dosage forms exhibit negligible dissolution indicating potentially poor bioavailability.
CoQ10 is a lipid-soluble compound found in the mitochondria of all living cells.
CoQlO, being lipid soluble, follows the same pathway as that of fats for its absorption in the body. This involves emulsification in the intestine (with the help of bile salts) and the formation of micelles prior to absorption. Among the other factors affecting the absorption of exogenously administered CoQ l0 are its particle size, degree of solubilization, and the type of food ingested with the supplement.
Although CoQlO is classified as a lipid soluble substance, its degree of solubility is extremely limited. Commercially available CoQl0 capsules contain either oil-based suspensions (softgels), or dry powder blends (hard gels). When tested in the laboratory, these products show a total lack of dissolution according to current USP methodology. Such lack of dissolution properties are often indicative of poor absorption and bioavailability.
In order to improve the dissolution profile and bioavailability of CoQl0, Tishcon Corp. has acquired an exclusive technology/process from BioSytes, USA, Inc.
This novel Bio-Solv® process has provided the key to the solubilization of CoQlO. Q-Gel® softsules® based on the Bio-Solv® process exhibit optimum dissolution, which is indicative of improved absorption/bioavailability.
Several human studies have been subsequently carried out to compare the relative bioavailability of Q-Gel® with other currently available dosage forms (softgels, tablets and capsules), and the data obtained from these studies clearly demonstrate that Q-Gel® is vastly superior (several times higher relative bioavailability than all other dosage forms tested).
This data was presented at the Annual Meeting of the American Society for Nutritional Sciences/Experimental Biology in New Orleans on April 9, 1997.
(Chopra, R., Goldman, R., Bhagavan, H.N., A new Coenzyme Q10 preparation with enhanced relative Bioavailability).
Q-Gel ®, the 100% HYDROSOLUBLE CoQ10, has been proven via seven separate relative bioavailability studies in human subjects, to be the most bioavailable CoQ10 oral supplement in the World! A relative bioavailability study in dogs has confirmed these findings. Additional studies have been carried out in rats to determine tissue uptake. Another bioavailability study carried out by an independent group has confirmed the superiority of Q-Gel over oil suspension softgels! In-vitro dissolution and cell-culture studies have also confirmed the absolute superiority of Q-Gel.
Solanova CoQ10 Q-gel
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