DHEA and Diabetes Protection – the Insulin connection

diabetesDiabetes is a metabolic disorder where your body no longer produces enough insulin, or your cells don’t use insulin efficiently.  Insulin is created in the pancreas and is essential for regulating the body's metabolism of sugars and starches. Insulin breaks down so it can be utilized by the body. The inability to produce enough insulin can lead to Diabetes.

Dr. Giuseppe Boccuzzi from the University of Turin, Italy, stated that, "Emerging evidence shows that oxidative stress plays a key role in macro- and micro-vascular complications of diabetes, suggesting that glycemic control is not the only goal in the treatment of diabetic patients....By restoring DHEA levels close to those found in young adults, oxidative imbalance will be reduced," Dr. Boccuzzi concluded. "This should be the way to counteract AGE formation in type 2 diabetic patients, likely preventing the progression of chronic complications."

In a recent study, diabetics who had taken DHEA had 50% less oxidative stress and glycation and significantly more antioxidants in the blood, including 35% more glutathione and 76% more vitamin E. The placebo group had no significant changes. Study authors concluded that DHEA might prevent cell damage from high blood sugar and counteract the complications in type 2 diabetes.

Way back in 1995 at a meeting entitled DHEA AND AGING in Washington DC, John Nestler in his talk hypothesized that the age-related drop in DHEA and DHEA-S, may be due in part to the normal age-related rise in circulating insulin levels. Thus increasing insulin, may indeed be one of the main reasons that DHEA declines with age, and an inverse relationship may indeed be possible; as DHEA levels are enhanced then insulin may drop.

There is fairly strong evidence that DHEA plays a protective role against diabetes; which is a primary risk factor for heart disease. Incidentally Low DHEA levels can be a predictor of heart disease  As far back as 1983, Dr. Les Coleman of the Jackson Laboratories in Maine, tested DHEA on mice that were specifically bred to develop diabetes. Despite a strong genetic disposition to develop both diabetes and obesity, these mice remained free of diabetes and maintained there normal weight. These studies and other experiments like them seem to  tell us that DHEA could be a potent tool in the prevention of Diabetes.




The Main Benefits of DHEA - includes new supporting research

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